We updated this post with the first shock of the day at 2:35 p.m. ET:
It's one-and-done for the Duke Blue Devils as their men's basketball team was beaten Friday by the Mercer Bears, 78-71, in the Division I men's basketball championship.
Mercer, a No. 14 seed in the Midwest region, was a huge underdog to the No. 3 seed Duke.
The win for Mercer, which has its main campus in Macon, Ga., is by far the biggest upset of the tournament so far. Heading into play, Duke was No. 8 in The Associated Press rankings. Mercer wasn't even among the nation's top 75 teams.